Aurelo
Do Folate and Vitamin B12 Work Together?
B12 and folic acid are both linked to homocysteine: B12 helps turn homocysteine into methionine, and B12 and folic acid supplements both lower homocysteine.[1]
Based on NIH Office of Dietary Supplements — Vitamin B12 fact sheet · Updated October 10, 2026
B12 and folic acid supplements both lower homocysteine.[1]
B12 helps convert homocysteine to methionine; homocysteine rises as B12 status declines and is also influenced by low folate levels.
Homocysteine rises as B12 status declines; B12 and folic acid supplements lower homocysteine.
Source [1]Vitamin B12: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. (ods.od.nih.gov)
Log your supplements and meals, and Aurelo flags pairings like this one in your own stack, with the days they happened.
Get started freeRelated
- Do Choline and Folate Work Together?Yes. Both donate methyl groups, and when folate is low the body needs more choline.
- Do You Need Black Pepper With Turmeric?In one study in healthy volunteers, 20 mg of piperine raised curcumin’s bioavailability about twenty-fold.
Sources
- Vitamin B12: Fact Sheet for Health Professionals. NIH Office of Dietary Supplements. ods.od.nih.gov
This page is general information from the cited sources, not medical advice. If you take prescription medication, are pregnant, or manage a health condition, check supplement changes with a pharmacist or doctor.